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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Opioid tolerance in methadone maintenance treatment: comparison of methadone and levomethadone in long-term treatment
|
|---|---|
| Published in |
Harm Reduction Journal, February 2016
|
| DOI | 10.1186/s12954-016-0095-0 |
| Pubmed ID | |
| Authors |
Stefan Gutwinski, Nikola Schoofs, Heiner Stuke, Thomas G. Riemer, Corinde E. Wiers, Felix Bermpohl |
| Abstract |
This study aimed to investigate the development of opioid tolerance in patients receiving long-term methadone maintenance treatment (MMT). A region-wide cross-sectional study was performed focusing on dosage and duration of treatment. Differences between racemic methadone and levomethadone were examined. All 20 psychiatric hospitals and all 110 outpatient clinics in Berlin licensed to offer MMT were approached in order to reach patients under MMT fulfilling the DSM IV criteria of opiate dependence. In the study, 720 patients treated with racemic methadone or levomethadone gave information on the dosage of treatment. Out of these, 679 patients indicated the duration of MMT. Treatment with racemic methadone was reported for 370 patients (54.5 %), with levomethadone for 309 patients (45.5 %). Mean duration of MMT was 7.5 years. We found a significant correlation between dosage and duration of treatment, both in a conjoint analysis for the two substances racemic methadone and levomethadone and for each substance separately. These effects remained significant when only patients receiving MMT for 1 year or longer were considered, indicating proceeding tolerance development in long-term treatment. When correlations were compared between racemic methadone and levomethadone, no significant difference was found. Our data show a tolerance development under long-term treatment with both racemic methadone and levomethadone. Tolerance development did not differ significantly between the two substances. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Italy | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 2% |
| Unknown | 45 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 20% |
| Student > Master | 6 | 13% |
| Student > Bachelor | 5 | 11% |
| Student > Postgraduate | 4 | 9% |
| Student > Ph. D. Student | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 16 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 26% |
| Neuroscience | 5 | 11% |
| Economics, Econometrics and Finance | 3 | 7% |
| Psychology | 3 | 7% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 16 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2017.
All research outputs
#12,946,234
of 22,849,304 outputs
Outputs from Harm Reduction Journal
#720
of 922 outputs
Outputs of similar age
#134,079
of 297,534 outputs
Outputs of similar age from Harm Reduction Journal
#2
of 10 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 922 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.8. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,534 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.