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Timing of malaria in pregnancy and impact on infant growth and morbidity: a cohort study in Uganda

Overview of attention for article published in Malaria Journal, February 2016
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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190 Mendeley
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Title
Timing of malaria in pregnancy and impact on infant growth and morbidity: a cohort study in Uganda
Published in
Malaria Journal, February 2016
DOI 10.1186/s12936-016-1135-7
Pubmed ID
Authors

Pierre De Beaudrap, Eleanor Turyakira, Carolyn Nabasumba, Benon Tumwebaze, Patrice Piola, Yap Boum II, Rose McGready

Abstract

Malaria in pregnancy (MiP) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-Saharan Africa. Understanding of the impact of MiP on infant growth and infant risk of malaria or morbidity is poorly characterized. The objective of this study was to describe the impact of MIP on subsequent infant growth, malaria and morbidity. Between 2006 and 2009, 82 % (832/1018) of pregnant women with live-born singletons and ultrasound determined gestational age were enrolled in a prospective cohort with active weekly screening and treatment for malaria. Infants were followed monthly for growth and morbidity and received active monthly screening and treatment for malaria during their first year of life. Multivariate analyses were performed to analyse the association between malaria exposure during pregnancy and infants' growth, malaria infections, diarrhoea episodes and acute respiratory infections. Median time of infant follow-up was 12 months and infants born to a mother who had MiP were at increased risk of impaired height and weight gain (-2.71 cm, 95 % CI -4.17 to -1.25 and -0.42 kg, 95 % CI -0.76 to -0.08 at 12 months for >1 MiP compared to no MiP) and of malaria infection (relative risk 10.42, 95 % CI 2.64-41.10 for infants born to mothers with placental malaria). The risks of infant growth restriction and infant malaria infection were maximal when maternal malaria occurred in the 12 weeks prior to delivery. Recurrent MiP was also associated with acute respiratory infection (RR 1.96, 95 % CI 1.25-3.06) and diarrhoea during infancy (RR 1.93, 95 % CI 1.02-3.66). This study shows that despite frequent active screening and prompt treatment of MiP, impaired growth and an increased risk of malaria and non-malaria infections can be observed in the infants. Effective preventive measures in pregnancy remain a research priority. This study was registered with ClinicalTrials.gov, number NCT00495508.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Brazil 1 <1%
Unknown 188 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 29 15%
Student > Ph. D. Student 28 15%
Researcher 26 14%
Student > Postgraduate 17 9%
Student > Bachelor 17 9%
Other 28 15%
Unknown 45 24%
Readers by discipline Count As %
Medicine and Dentistry 51 27%
Nursing and Health Professions 21 11%
Agricultural and Biological Sciences 19 10%
Immunology and Microbiology 15 8%
Social Sciences 5 3%
Other 29 15%
Unknown 50 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2017.
All research outputs
#6,864,712
of 22,849,304 outputs
Outputs from Malaria Journal
#2,054
of 5,573 outputs
Outputs of similar age
#94,678
of 297,534 outputs
Outputs of similar age from Malaria Journal
#59
of 185 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 5,573 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,534 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 185 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.