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X Demographics
Mendeley readers
Attention Score in Context
| Title |
N- and O-glycan cell surface protein modifications associated with cellular senescence and human aging
|
|---|---|
| Published in |
Cell & Bioscience, February 2016
|
| DOI | 10.1186/s13578-016-0079-5 |
| Pubmed ID | |
| Authors |
Yoko Itakura, Norihiko Sasaki, Daisuke Kami, Satoshi Gojo, Akihiro Umezawa, Masashi Toyoda |
| Abstract |
Glycans play essential roles in biological functions such as differentiation and cancer. Recently, glycans have been considered as biomarkers for physiological aging. However, details regarding the specific glycans involved are limited. Here, we investigated cellular senescence- and human aging-dependent glycan changes in human diploid fibroblasts derived from differently aged skin donors using a lectin microarray. We found that α2-6sialylated glycans in particular differed between elderly- and fetus-derived cells at early passage. However, both cell types exhibited sequentially decreasing α2-3sialylated O-glycan structures during the cellular senescence process and showed similar overall glycan profiles. We observed a senescence-associated decrease in sialylation and increase in galactose exposure. Therefore, glycan profiling using lectin microarrays might be useful for the characterization of biomarkers of aging. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Unknown | 62 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 17% |
| Student > Master | 11 | 17% |
| Researcher | 8 | 13% |
| Student > Bachelor | 7 | 11% |
| Student > Doctoral Student | 5 | 8% |
| Other | 7 | 11% |
| Unknown | 14 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 48% |
| Agricultural and Biological Sciences | 7 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Engineering | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 17 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2021.
All research outputs
#4,028,323
of 22,849,304 outputs
Outputs from Cell & Bioscience
#97
of 932 outputs
Outputs of similar age
#62,058
of 298,010 outputs
Outputs of similar age from Cell & Bioscience
#4
of 18 outputs
Altmetric has tracked 22,849,304 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 932 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,010 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.