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NPR2 is involved in FSH-mediated mouse oocyte meiotic resumption

Overview of attention for article published in Journal of Ovarian Research, February 2016
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  • Among the highest-scoring outputs from this source (#48 of 152)
  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

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2 tweeters

Citations

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9 Dimensions

Readers on

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13 Mendeley
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Title
NPR2 is involved in FSH-mediated mouse oocyte meiotic resumption
Published in
Journal of Ovarian Research, February 2016
DOI 10.1186/s13048-016-0218-y
Pubmed ID
Authors

Lei Yang, Qiang Wei, Wei Li, Qihui Xi, Xiaoe Zhao, Baohua Ma

Abstract

Previous studies have reported that follicle-stimulating hormone (FSH) is often added to culture media to induce oocyte meiotic resumption and maturation and to improve subsequent embryonic development during in vitro maturation (IVM). However, the underlying mechanisms remain unclear. Cumulus-oocyte complexes (COCs) were collected from ovaries 46-48 h after the female mice were intraperitoneally injected with 8 IU equine chorionic gonadotropin (eCG) and then the COCs were cultured in different medium. qRT-PCR analysis was used to assess mRNA expression of EGF-like factors and natriuretic peptide receptor 2 (NPR2). Western Blot analysis was used to assess phosphorylation of mitogen-activated protein kinase 3/1 (MAPK3/1). The oocytes were morphologically assessed for meiotic resumption. FSH stimulated the expression of EGF-like factors, the activation of MAPK3/1, a decrease in NPR2 mRNA and oocyte meiotic resumption. Moreover, the FSH-induced decrease in NPR2 and oocyte meiotic resumption occurred via the MAPK3/1 singling pathway, which was activated by the epidermal growth factor receptor (EGFR) pathway. NPR2 is involved in FSH-mediated oocyte meiotic resumption, and this process is associated with the EGFR and MAPK3/1 signaling pathways.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 23%
Student > Doctoral Student 3 23%
Other 2 15%
Student > Master 2 15%
Professor 1 8%
Other 2 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 31%
Veterinary Science and Veterinary Medicine 3 23%
Medicine and Dentistry 3 23%
Biochemistry, Genetics and Molecular Biology 2 15%
Psychology 1 8%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2016.
All research outputs
#3,524,196
of 7,313,486 outputs
Outputs from Journal of Ovarian Research
#48
of 152 outputs
Outputs of similar age
#140,117
of 283,612 outputs
Outputs of similar age from Journal of Ovarian Research
#4
of 12 outputs
Altmetric has tracked 7,313,486 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 152 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,612 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.