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Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

Overview of attention for article published in Molecular Neurodegeneration, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

twitter
2 tweeters
patent
3 patents

Readers on

mendeley
78 Mendeley
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Title
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Published in
Molecular Neurodegeneration, January 2012
DOI 10.1186/1750-1326-7-3
Pubmed ID
Authors

Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven

Abstract

We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regulatory regions in an extended Flanders-Belgian cohort of Caucasian AD patients and control individuals (n = 1930). Moreover, we have replicated genetic findings by targeted resequencing in independent Caucasian cohorts of French (n = 2182) and Canadian (n = 573) origin and by performing meta-analysis combining our data with previous genetic CLU screenings.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
United Kingdom 1 1%
Canada 1 1%
Spain 1 1%
United States 1 1%
Unknown 73 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 24%
Researcher 16 21%
Student > Master 15 19%
Student > Postgraduate 4 5%
Professor 4 5%
Other 10 13%
Unknown 10 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 29%
Biochemistry, Genetics and Molecular Biology 16 21%
Medicine and Dentistry 10 13%
Neuroscience 7 9%
Psychology 1 1%
Other 7 9%
Unknown 14 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2021.
All research outputs
#3,515,346
of 19,569,206 outputs
Outputs from Molecular Neurodegeneration
#412
of 750 outputs
Outputs of similar age
#36,290
of 233,447 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 14 outputs
Altmetric has tracked 19,569,206 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 750 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.2. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,447 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.