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Mendeley readers
| Title |
STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas
|
|---|---|
| Published in |
Breast Cancer Research, January 2012
|
| DOI | 10.1186/bcr3100 |
| Pubmed ID | |
| Authors |
Szeman Ruby Chan, William Vermi, Jingqin Luo, Laura Lucini, Charles Rickert, Amy M Fowler, Silvia Lonardi, Cora Arthur, Larry JT Young, David E Levy, Michael J Welch, Robert D Cardiff, Robert D Schreiber |
| Abstract |
Although breast cancers expressing estrogen receptor-α (ERα) and progesterone receptors (PR) are the most common form of mammary malignancy in humans, it has been difficult to develop a suitable mouse model showing similar steroid hormone responsiveness. STAT transcription factors play critical roles in mammary gland tumorigenesis, but the precise role of STAT1 remains unclear. Herein, we show that a subset of human breast cancers display reduced STAT1 expression and that mice lacking STAT1 surprisingly develop ERα+/PR+ mammary tumors. |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Poland | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 126 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 24% |
| Researcher | 21 | 16% |
| Student > Bachelor | 12 | 9% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 8 | 6% |
| Other | 15 | 12% |
| Unknown | 31 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 29% |
| Biochemistry, Genetics and Molecular Biology | 28 | 22% |
| Medicine and Dentistry | 16 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Immunology and Microbiology | 4 | 3% |
| Other | 6 | 5% |
| Unknown | 33 | 26% |