A Wnt1 regulated Frizzled-1/β-Cateninsignaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
Francesca L'Episcopo, Maria F Serapide, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria C Morale, Stefano Pluchino, Bianca Marchetti
Abstract
Dopamine-synthesizing (dopaminergic, DA) neurons in the ventral midbrain (VM) constitute a pivotal neuronal population controlling motor behaviors, cognitive and affective brain functions, which generation critically relies on the activation of Wingless-type MMTV integration site (Wnt)/β-catenin pathway in their progenitors. In Parkinson's disease, DA cell bodies within the substantia nigra pars compacta (SNpc) progressively degenerate, with causes and mechanisms poorly understood. Emerging evidence suggests that Wnt signaling via Frizzled (Fzd) receptors may play a role in different degenerative states, but little is known about Wnt signaling in the adult midbrain. Using in vitro and in vivo model systems of DA degeneration, along with functional studies in both intact and SN lesioned mice, we herein highlight an intrinsic Wnt1/Fzd-1/β-catenin tone critically contributing to the survival and protection of adult midbrain DA neurons.
Pharmacology, Toxicology and Pharmaceutical Science
8
6%
Medicine and Dentistry
5
4%
Other
11
9%
Unknown
34
27%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2024.
All research outputs
#5,001,688
of 26,503,921 outputs
Outputs from Molecular Neurodegeneration
#657
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Outputs of similar age
#24,904
of 131,544 outputs
Outputs of similar age from Molecular Neurodegeneration
#4
of 16 outputs
Altmetric has tracked 26,503,921 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,018 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.4. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.
