You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
| Title |
Protein dynamics and conformational selection in bidirectional signal transduction
|
|---|---|
| Published in |
BMC Biology, January 2012
|
| DOI | 10.1186/1741-7007-10-2 |
| Pubmed ID | |
| Authors |
Ruth Nussinov, Buyong Ma |
| Abstract |
Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous ensemble and loop dynamics explain how the EphA4 receptor is able to bind multiple A- and B-ephrin ligands and small molecules via conformational selection, which helps to fine-tune cellular signal response in both receptor and ligand cells. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| United Kingdom | 1 | 25% |
| Mexico | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Chile | 1 | 2% |
| Australia | 1 | 2% |
| Turkey | 1 | 2% |
| Israel | 1 | 2% |
| Singapore | 1 | 2% |
| Argentina | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 56 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 22% |
| Student > Ph. D. Student | 13 | 20% |
| Student > Master | 8 | 12% |
| Professor | 5 | 8% |
| Student > Bachelor | 5 | 8% |
| Other | 15 | 23% |
| Unknown | 5 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 37% |
| Biochemistry, Genetics and Molecular Biology | 10 | 15% |
| Chemistry | 9 | 14% |
| Physics and Astronomy | 3 | 5% |
| Computer Science | 3 | 5% |
| Other | 9 | 14% |
| Unknown | 7 | 11% |