Title |
Core module biomarker identification with network exploration for breast cancer metastasis
|
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Published in |
BMC Bioinformatics, January 2012
|
DOI | 10.1186/1471-2105-13-12 |
Pubmed ID | |
Authors |
Ruoting Yang, Bernie J Daigle, Linda R Petzold, Francis J Doyle |
Abstract |
In a complex disease, the expression of many genes can be significantly altered, leading to the appearance of a differentially expressed "disease module". Some of these genes directly correspond to the disease phenotype, (i.e. "driver" genes), while others represent closely-related first-degree neighbours in gene interaction space. The remaining genes consist of further removed "passenger" genes, which are often not directly related to the original cause of the disease. For prognostic and diagnostic purposes, it is crucial to be able to separate the group of "driver" genes and their first-degree neighbours, (i.e. "core module") from the general "disease module". |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Mexico | 1 | 2% |
Hungary | 1 | 2% |
Germany | 1 | 2% |
Unknown | 43 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 45% |
Researcher | 8 | 17% |
Professor | 3 | 6% |
Student > Master | 3 | 6% |
Student > Bachelor | 2 | 4% |
Other | 7 | 15% |
Unknown | 3 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 30% |
Computer Science | 11 | 23% |
Engineering | 7 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Mathematics | 2 | 4% |
Other | 4 | 9% |
Unknown | 5 | 11% |