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Development and validation of a repharsed phase- HPLC method for simultaneous determination of rosiglitazone and glimepiride in combined dosage forms and human plasma

Overview of attention for article published in BMC Chemistry, January 2012
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Title
Development and validation of a repharsed phase- HPLC method for simultaneous determination of rosiglitazone and glimepiride in combined dosage forms and human plasma
Published in
BMC Chemistry, January 2012
DOI 10.1186/1752-153x-6-9
Pubmed ID
Authors

Nahed M El-Enany, Amina A Abdelal, Fathalla F Belal, Yoshinori I Itoh, Mitsuhiro N Nakamura

Abstract

Rosiglitazone (ROZ) and glimepiride (GLM) are antidiabetic agents used in the treatment of type 2 diabetes mellitus. A survey of the literature reveals that only one spectrophotometric method has been reported for the simultaneous determination of ROS and GLM in pharmaceutical preparations. However the reported method suffers from the low sensitivity, for this reason, our target was to develop a simple sensitive HPLC method for the simultaneous determination of ROZ and GLM in their combined dosage forms and plasma.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 3%
Pakistan 1 3%
Unknown 38 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 13%
Researcher 5 13%
Professor 5 13%
Student > Master 5 13%
Student > Bachelor 3 8%
Other 8 20%
Unknown 9 23%
Readers by discipline Count As %
Chemistry 6 15%
Medicine and Dentistry 5 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Agricultural and Biological Sciences 4 10%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 4 10%
Unknown 15 38%