Title |
Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors
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Published in |
Journal of Translational Medicine, December 2011
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DOI | 10.1186/1479-5876-9-221 |
Pubmed ID | |
Authors |
Enrico P Spugnini, Alfonso Baldi, Sabrina Buglioni, Francesca Carocci, Giulia Milesi de Bazzichini, Gianluca Betti, Ilaria Pantaleo, Francesco Menicagli, Gennaro Citro, Stefano Fais |
Abstract |
The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs. Mechanisms underlying this resistance are far from being entirely known. A very efficient mechanism of tumor resistance to drugs is related to the modification of tumour microenvironment through changes in the extracellular and intracellular pH. The acidification of tumor microenvironment depends on proton pumps that actively pump protons outside the cells, mostly to avoid intracellular acidification. In fact, we have shown in pre-clinical settings as pre-treatment with proton-pumps inhibitors (PPI) increase tumor cell and tumor responsiveness to chemotherapeutics. In this study pet with spontaneously occurring cancer proven refractory to conventional chemotherapy have been recruited in a compassionate study. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
Grenada | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 75 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 17% |
Researcher | 10 | 13% |
Other | 7 | 9% |
Student > Doctoral Student | 6 | 8% |
Student > Postgraduate | 6 | 8% |
Other | 13 | 17% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 29% |
Veterinary Science and Veterinary Medicine | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Psychology | 6 | 8% |
Agricultural and Biological Sciences | 5 | 7% |
Other | 7 | 9% |
Unknown | 22 | 29% |