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Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1

Overview of attention for article published in Virology Journal, January 2012
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Title
Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1
Published in
Virology Journal, January 2012
DOI 10.1186/1743-422x-9-33
Pubmed ID
Authors

Vanessa Pirrone, Shendra Passic, Brian Wigdahl, Fred C Krebs

Abstract

Continued efforts are being directed toward the development of microbicides that will be used to reduce or eliminate the risk of HIV-1 sexual transmission. Unfortunately, clinical trials involving polyanion-containing microbicide formulations, including Carraguard (λ-carrageenan [LC]) and Ushercell (cellulose sulfate [CS]) demonstrated that these products were ineffective and may have, in some circumstances, increased the risk of HIV-1 infection. These findings prompted reassessments of the in vitro activities of these agents to determine whether variables that can affect agent safety and efficacy had been overlooked during preclinical testing. One such variable is product retention and loss following topical application.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 18%
Professor > Associate Professor 3 18%
Student > Ph. D. Student 3 18%
Student > Doctoral Student 2 12%
Other 2 12%
Other 3 18%
Unknown 1 6%
Readers by discipline Count As %
Immunology and Microbiology 5 29%
Biochemistry, Genetics and Molecular Biology 3 18%
Medicine and Dentistry 3 18%
Social Sciences 1 6%
Chemistry 1 6%
Other 1 6%
Unknown 3 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2012.
All research outputs
#20,154,661
of 22,662,201 outputs
Outputs from Virology Journal
#2,858
of 3,025 outputs
Outputs of similar age
#222,855
of 246,248 outputs
Outputs of similar age from Virology Journal
#65
of 87 outputs
Altmetric has tracked 22,662,201 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,025 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,248 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.