Title |
Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1
|
---|---|
Published in |
Virology Journal, January 2012
|
DOI | 10.1186/1743-422x-9-33 |
Pubmed ID | |
Authors |
Vanessa Pirrone, Shendra Passic, Brian Wigdahl, Fred C Krebs |
Abstract |
Continued efforts are being directed toward the development of microbicides that will be used to reduce or eliminate the risk of HIV-1 sexual transmission. Unfortunately, clinical trials involving polyanion-containing microbicide formulations, including Carraguard (λ-carrageenan [LC]) and Ushercell (cellulose sulfate [CS]) demonstrated that these products were ineffective and may have, in some circumstances, increased the risk of HIV-1 infection. These findings prompted reassessments of the in vitro activities of these agents to determine whether variables that can affect agent safety and efficacy had been overlooked during preclinical testing. One such variable is product retention and loss following topical application. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 18% |
Professor > Associate Professor | 3 | 18% |
Student > Ph. D. Student | 3 | 18% |
Student > Doctoral Student | 2 | 12% |
Other | 2 | 12% |
Other | 3 | 18% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 5 | 29% |
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Medicine and Dentistry | 3 | 18% |
Social Sciences | 1 | 6% |
Chemistry | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 18% |