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Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus

Overview of attention for article published in BMC Neuroscience, January 2012
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Title
Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus
Published in
BMC Neuroscience, January 2012
DOI 10.1186/1471-2202-13-14
Pubmed ID
Authors

Ilse Riebe, Eric Hanse

Abstract

The impact of a given presynaptic neuron on the firing probability of the postsynaptic neuron critically depends on the number of functional release sites that connect the two neurons. One way of determining the average functional synaptic connectivity onto a postsynaptic neuron is to compare the amplitudes of action potential dependent spontaneous synaptic currents with the amplitude of the synaptic currents that are independent of action potentials ("minis"). With this method it has been found that average synaptic connectivity between glutamatergic CA3 and CA1 pyramidal cells increases from single connections in the neonatal rat, to multiple connections in the young adult rat. On the other hand, γ-aminobutyric acid (GABA)ergic interneurons form multiple connections onto CA1 pyramidal cells already in the neonatal rat, and the degree of multiple GABAergic connectivity is preserved into adulthood. In the present study, we have examined the development of glutamate and GABA connectivity onto GABAergic CA1 stratum radiatum interneurons in the hippocampal slice, and compared this to the connectivity onto CA1 pyramidal neurons.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Hungary 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 38%
Researcher 9 23%
Student > Doctoral Student 4 10%
Student > Master 4 10%
Professor > Associate Professor 2 5%
Other 3 8%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 44%
Neuroscience 11 28%
Medicine and Dentistry 4 10%
Psychology 2 5%
Nursing and Health Professions 1 3%
Other 1 3%
Unknown 3 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2012.
All research outputs
#18,304,230
of 22,662,201 outputs
Outputs from BMC Neuroscience
#878
of 1,240 outputs
Outputs of similar age
#196,373
of 246,172 outputs
Outputs of similar age from BMC Neuroscience
#17
of 22 outputs
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So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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