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Mendeley readers
Attention Score in Context
| Title |
Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia
|
|---|---|
| Published in |
Journal of Neuroinflammation, January 2012
|
| DOI | 10.1186/1742-2094-9-2 |
| Pubmed ID | |
| Authors |
Antonio CP de Oliveira, Eduardo Candelario-Jalil, Julia Langbein, Lena Wendeburg, Harsharan S Bhatia, Johannes CM Schlachetzki, Knut Biber, Bernd L Fiebich |
| Abstract |
Microglia are considered a major target for modulating neuroinflammatory and neurodegenerative disease processes. Upon activation, microglia secrete inflammatory mediators that contribute to the resolution or to further enhancement of damage in the central nervous system (CNS). Therefore, it is important to study the intracellular pathways that are involved in the expression of the inflammatory mediators. Particularly, the role of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and glycogen synthase kinase-3 (GSK-3) pathways in activated microglia is unclear. Thus, in the present study we investigated the role of Akt and its downstream pathways, GSK-3 and mTOR, in lipopolysaccharide (LPS)-activated primary rat microglia by pharmacological inhibition of these pathways in regard to the expression of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES-1) and to the production of prostaglandin (PG) E2 and PGD2. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Mexico | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 65 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 22% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Bachelor | 8 | 12% |
| Student > Master | 7 | 10% |
| Professor > Associate Professor | 6 | 9% |
| Other | 9 | 13% |
| Unknown | 14 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 22% |
| Medicine and Dentistry | 12 | 18% |
| Neuroscience | 9 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 16 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2012.
All research outputs
#15,241,801
of 22,662,201 outputs
Outputs from Journal of Neuroinflammation
#1,727
of 2,604 outputs
Outputs of similar age
#163,196
of 244,202 outputs
Outputs of similar age from Journal of Neuroinflammation
#16
of 31 outputs
Altmetric has tracked 22,662,201 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,604 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,202 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.