Title |
MetaMerge: scaling up genome-scale metabolic reconstructions with application to Mycobacterium tuberculosis
|
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Published in |
Genome Biology, January 2012
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DOI | 10.1186/gb-2012-13-1-r6 |
Pubmed ID | |
Authors |
Leonid Chindelevitch, Sarah Stanley, Deborah Hung, Aviv Regev, Bonnie Berger |
Abstract |
Reconstructed models of metabolic networks are widely used for studying metabolism in various organisms. Many different reconstructions of the same organism often exist concurrently, forcing researchers to choose one of them at the exclusion of the others. We describe MetaMerge, an algorithm for semi-automatically reconciling a pair of existing metabolic network reconstructions into a single metabolic network model. We use MetaMerge to combine two published metabolic networks for Mycobacterium tuberculosis into a single network, which allows many reactions that could not be active in the individual models to become active, and predicts essential genes with a higher positive predictive value. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Portugal | 1 | <1% |
Germany | 1 | <1% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
Lithuania | 1 | <1% |
France | 1 | <1% |
United Kingdom | 1 | <1% |
South Africa | 1 | <1% |
Other | 2 | 2% |
Unknown | 95 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 34 | 32% |
Researcher | 19 | 18% |
Student > Master | 18 | 17% |
Other | 7 | 7% |
Professor | 6 | 6% |
Other | 14 | 13% |
Unknown | 9 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 45 | 42% |
Computer Science | 19 | 18% |
Biochemistry, Genetics and Molecular Biology | 17 | 16% |
Engineering | 4 | 4% |
Mathematics | 2 | 2% |
Other | 6 | 6% |
Unknown | 14 | 13% |