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Gentamicin supplemented polyvinylidenfluoride mesh materials enhance tissue integration due to a transcriptionally reduced MMP-2 protein expression

Overview of attention for article published in BMC Surgery, January 2012
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Title
Gentamicin supplemented polyvinylidenfluoride mesh materials enhance tissue integration due to a transcriptionally reduced MMP-2 protein expression
Published in
BMC Surgery, January 2012
DOI 10.1186/1471-2482-12-1
Pubmed ID
Authors

Marcel Binnebösel, Klaus T von Trotha, Christina Ricken, Christian D Klink, Karsten Junge, Joachim Conze, Marc Jansen, Ulf P Neumann, Petra Lynen Jansen

Abstract

A beneficial effect of gentamicin supplemented mesh material on tissue integration is known. To further elucidate the interaction of collagen and MMP-2 in chronic foreign body reaction and to determine the significance of the MMP-2-specific regulatory element (RE-1) that is known to mediate 80% of the MMP-2 promoter activity, the spatial and temporal transcriptional regulation of the MMP-2 gene was analyzed at the cellular level.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 17%
Student > Ph. D. Student 4 17%
Professor > Associate Professor 3 13%
Student > Bachelor 2 9%
Other 1 4%
Other 3 13%
Unknown 6 26%
Readers by discipline Count As %
Medicine and Dentistry 8 35%
Engineering 3 13%
Agricultural and Biological Sciences 2 9%
Social Sciences 2 9%
Linguistics 1 4%
Other 1 4%
Unknown 6 26%