Title |
Mining multi-item drug adverse effect associations in spontaneous reporting systems
|
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Published in |
BMC Bioinformatics, October 2010
|
DOI | 10.1186/1471-2105-11-s9-s7 |
Pubmed ID | |
Authors |
Rave Harpaz, Herbert S Chase, Carol Friedman |
Abstract |
Multi-item adverse drug event (ADE) associations are associations relating multiple drugs to possibly multiple adverse events. The current standard in pharmacovigilance is bivariate association analysis, where each single drug-adverse effect combination is studied separately. The importance and difficulty in the detection of multi-item ADE associations was noted in several prominent pharmacovigilance studies. In this paper we examine the application of a well established data mining method known as association rule mining, which we tailored to the above problem, and demonstrate its value. The method was applied to the FDAs spontaneous adverse event reporting system (AERS) with minimal restrictions and expectations on its output, an experiment that has not been previously done on the scale and generality proposed in this work. |
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Geographical breakdown
Country | Count | As % |
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United States | 3 | 2% |
Japan | 2 | 1% |
Brazil | 1 | <1% |
Israel | 1 | <1% |
Canada | 1 | <1% |
Bulgaria | 1 | <1% |
Finland | 1 | <1% |
Slovenia | 1 | <1% |
Unknown | 123 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 25% |
Student > Master | 18 | 13% |
Researcher | 15 | 11% |
Student > Bachelor | 10 | 7% |
Student > Doctoral Student | 9 | 7% |
Other | 29 | 22% |
Unknown | 20 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 32 | 24% |
Medicine and Dentistry | 27 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 12% |
Agricultural and Biological Sciences | 10 | 7% |
Social Sciences | 4 | 3% |
Other | 20 | 15% |
Unknown | 25 | 19% |