Title |
Anidulafungin compared with fluconazole for treatment of candidemia and other forms of invasive candidiasis caused by Candida albicans: a multivariate analysis of factors associated with improved outcome
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Published in |
BMC Infectious Diseases, September 2011
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DOI | 10.1186/1471-2334-11-261 |
Pubmed ID | |
Authors |
Annette C Reboli, Andrew F Shorr, Coleman Rotstein, Peter G Pappas, Daniel H Kett, Haran T Schlamm, Arlene L Reisman, Pinaki Biswas, Thomas J Walsh |
Abstract |
Candida albicans is the most common cause of candidemia and other forms of invasive candidiasis. Systemic infections due to C. albicans exhibit good susceptibility to fluconazole and echinocandins. However, the echinocandin anidulafungin was recently demonstrated to be more effective than fluconazole for systemic Candida infections in a randomized, double-blind trial among 245 patients. In that trial, most infections were caused by C. albicans, and all respective isolates were susceptible to randomized study drug. We sought to better understand the factors associated with the enhanced efficacy of anidulafungin and hypothesized that intrinsic properties of the antifungal agents contributed to the treatment differences. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Unknown | 120 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 16% |
Student > Master | 15 | 12% |
Other | 12 | 10% |
Student > Bachelor | 8 | 7% |
Student > Ph. D. Student | 7 | 6% |
Other | 37 | 31% |
Unknown | 23 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 54 | 45% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 9% |
Agricultural and Biological Sciences | 11 | 9% |
Immunology and Microbiology | 4 | 3% |
Unspecified | 3 | 2% |
Other | 9 | 7% |
Unknown | 29 | 24% |