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Is thyroid status associated with cognitive impairment in elderly patients in China?

Overview of attention for article published in BMC Endocrine Disorders, February 2016
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Title
Is thyroid status associated with cognitive impairment in elderly patients in China?
Published in
BMC Endocrine Disorders, February 2016
DOI 10.1186/s12902-016-0092-z
Pubmed ID
Authors

Yao Hu, Zhi-cheng Wang, Qi-hao Guo, Wei Cheng, Yan-wen Chen

Abstract

The relationship between alterations in thyroid function and cognitive deficits has been investigated in several previous studies. Hypo-or hyperthyroidism and, to a lesser extent, subclinical thyroid dysfunction can negatively affect cognitive performance. However, limited data are available on the potential association of thyroid function with mild cognitive impairment (MCI) and Alzheimer's disease (AD) in the elderly Chinese population. In the present study focusing on a population of elderly Chinese individuals ≥ 50 years of age, 77 cognitively normal controls, 64 patients with MCI, and 154 patients diagnosed with AD underwent assessment of thyroid status using thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) levels as variables. Cognitive function was evaluated with the aid of comprehensive neuropsychological tests, such as the Mini-Mental State Examination (MMSE) and Memory and Executive Screening (MES). Overall, 88.1 % of the subjects displayed normal thyroid function, 4.7 % were diagnosed with clinical hypothyroidism, 3.1 % with subclinical hypothyroidism, and 4.1 % with subclinical hyperthyroidism. After adjusting for covariates (age, sex, education years and body mass index), no association was evident between mild cognitive impairment or AD and thyroid dysfunction. However, lower serum TSH was correlated with risk of AD (odds ratio [OR]: 2.78, 95 % confidence interval [95% CI]: 1.11-6.99). Neither hypothyroidism nor subclinical hyperthyroidism was associated with AD and MCI in this population-based elderly Chinese cohort. Our findings need to be confirmed in a longitudinal study.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 101 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 17%
Student > Bachelor 16 16%
Researcher 12 12%
Student > Doctoral Student 7 7%
Other 6 6%
Other 16 16%
Unknown 27 27%
Readers by discipline Count As %
Medicine and Dentistry 23 23%
Psychology 12 12%
Neuroscience 9 9%
Nursing and Health Professions 7 7%
Social Sciences 5 5%
Other 9 9%
Unknown 36 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2016.
All research outputs
#15,361,255
of 22,851,489 outputs
Outputs from BMC Endocrine Disorders
#401
of 758 outputs
Outputs of similar age
#176,450
of 297,882 outputs
Outputs of similar age from BMC Endocrine Disorders
#4
of 8 outputs
Altmetric has tracked 22,851,489 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 758 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,882 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.