Title |
Rationale and design of DECISION: a double-blind, randomized, placebo-controlled phase III trial evaluating the efficacy and safety of sorafenib in patients with locally advanced or metastatic radioactive iodine (RAI)-refractory, differentiated thyroid cancer
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Published in |
BMC Cancer, August 2011
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DOI | 10.1186/1471-2407-11-349 |
Pubmed ID | |
Authors |
Marcia S Brose, Christopher M Nutting, Steven I Sherman, Young Kee Shong, Johannes WA Smit, Gerhard Reike, John Chung, Joachim Kalmus, Christian Kappeler, Martin Schlumberger |
Abstract |
The incidence of thyroid cancer and the number of patients who die from this disease are increasing globally. Differentiated thyroid cancer (DTC) is the histologic subtype present in most patients and is primarily responsible for the increased overall incidence of thyroid cancer. Sorafenib is a multikinase inhibitor that targets several molecular signals believed to be involved in the pathogenesis of thyroid cancer, including those implicated in DTC. In phase II studies of patients with DTC, sorafenib treatment has yielded a median progression-free survival (PFS) of 58 to 84 weeks and disease control rates of 59% to 100%. The DECISION trial was designed to assess the ability of sorafenib to improve PFS in patients with locally advanced or metastatic, radioactive iodine (RAI)-refractory DTC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
France | 1 | <1% |
Brazil | 1 | <1% |
China | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 96 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 14% |
Student > Ph. D. Student | 12 | 12% |
Other | 10 | 10% |
Student > Master | 8 | 8% |
Professor | 8 | 8% |
Other | 30 | 29% |
Unknown | 20 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 53 | 52% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Agricultural and Biological Sciences | 3 | 3% |
Nursing and Health Professions | 3 | 3% |
Other | 9 | 9% |
Unknown | 23 | 23% |