Title |
Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety
|
---|---|
Published in |
International Archives of Medicine, February 2012
|
DOI | 10.1186/1755-7682-5-5 |
Pubmed ID | |
Authors |
Jorge Paz Rodriguez, Michael P Murphy, Soonjun Hong, Marialaura Madrigal, Keith L March, Boris Minev, Robert J Harman, Chien-Shing Chen, Ruben Berrocal Timmons, Annette M Marleau, Neil H Riordan |
Abstract |
Advancements in rheumatoid arthritis (RA) treatment protocols and introduction of targeted biological therapies have markedly improved patient outcomes, despite this, up to 50% of patients still fail to achieve a significant clinical response. In veterinary medicine, stem cell therapy in the form of autologous stromal vascular fraction (SVF) is an accepted therapeutic modality for degenerative conditions with 80% improvement and no serious treatment associated adverse events reported. Clinical translation of SVF therapy relies on confirmation of veterinary findings in targeted patient populations. Here we describe the rationale and preclinical data supporting the use of autologous SVF in treatment of RA, as well as provide 1, 3, 6, and 13 month safety outcomes in 13 RA patients treated with this approach. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Singapore | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 11% |
Student > Ph. D. Student | 4 | 5% |
Student > Bachelor | 2 | 3% |
Professor | 2 | 3% |
Other | 2 | 3% |
Other | 4 | 5% |
Unknown | 52 | 70% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 11% |
Agricultural and Biological Sciences | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Nursing and Health Professions | 1 | 1% |
Veterinary Science and Veterinary Medicine | 1 | 1% |
Other | 4 | 5% |
Unknown | 55 | 74% |