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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
|
|---|---|
| Published in |
Journal of Neuroinflammation, December 2009
|
| DOI | 10.1186/1742-2094-6-41 |
| Pubmed ID | |
| Authors |
Antero Salminen, Anu Kauppinen, Tiina Suuronen, Kai Kaarniranta, Johanna Ojala |
| Abstract |
The endoplasmic reticulum (ER) is involved in several crucial cellular functions, e.g. protein folding and quality control, maintenance of Ca2+ balance, and cholesterol synthesis. Many genetic and environmental insults can disturb the function of ER and induce ER stress. ER contains three branches of stress sensors, i.e. IRE1, PERK and ATF6 transducers, which recognize the misfolding of proteins in ER and activate a complex signaling network to generate the unfolded protein response (UPR). Alzheimer's disease (AD) is a progressive neurodegenerative disorder involving misfolding and aggregation of proteins in conjunction with prolonged cellular stress, e.g. in redox regulation and Ca2+ homeostasis. Emerging evidence indicates that the UPR is activated in neurons but not in glial cells in AD brains. Neurons display pPERK, peIF2alpha and pIRE1alpha immunostaining along with abundant diffuse staining of phosphorylated tau protein. Recent studies have demonstrated that ER stress can also induce an inflammatory response via different UPR transducers. The most potent pathways are IRE1-TRAF2, PERK-eIF2alpha, PERK-GSK-3, ATF6-CREBH, as well as inflammatory caspase-induced signaling pathways. We will describe the mechanisms which could link the ER stress of neurons to the activation of the inflammatory response and the evolution of pathological changes in AD. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| Georgia | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 271 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| India | 2 | <1% |
| United Kingdom | 2 | <1% |
| Brazil | 1 | <1% |
| Norway | 1 | <1% |
| Canada | 1 | <1% |
| Portugal | 1 | <1% |
| Japan | 1 | <1% |
| China | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 257 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 21% |
| Researcher | 47 | 17% |
| Student > Master | 30 | 11% |
| Student > Bachelor | 29 | 11% |
| Student > Doctoral Student | 17 | 6% |
| Other | 51 | 19% |
| Unknown | 39 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 81 | 30% |
| Biochemistry, Genetics and Molecular Biology | 45 | 17% |
| Neuroscience | 42 | 15% |
| Medicine and Dentistry | 21 | 8% |
| Chemistry | 9 | 3% |
| Other | 24 | 9% |
| Unknown | 49 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2018.
All research outputs
#7,148,499
of 25,373,627 outputs
Outputs from Journal of Neuroinflammation
#1,237
of 2,951 outputs
Outputs of similar age
#42,559
of 172,187 outputs
Outputs of similar age from Journal of Neuroinflammation
#3
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,187 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.