Title |
Combination of long-acting HIV fusion inhibitor albuvirtide and LPV/r showed potent efficacy in HIV-1 patients
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Published in |
AIDS Research and Therapy, February 2016
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DOI | 10.1186/s12981-016-0091-1 |
Pubmed ID | |
Authors |
Hongwei Zhang, Hongwei Zhang, Ronghua Jin, Cheng Yao, Tong Zhang, Meixia Wang, Wei Xia, Haiyan Peng, Xiaojuan Wang, Rongjian Lu, Changjin Wang, Dong Xie, Hao Wu |
Abstract |
Long acting antiretroviral drugs represent a promising approach for chronic treatment of HIV infection. Here, we study the efficacy and safety of albuvirtide (ABT), an HIV-1 fusion inhibitor with a half life of 11-12 days in human. ABT was evaluated in a 7-week, open-label and randomized trial, combining with LPV/r. Twenty HIV-1-infected adults were assigned to two dose groups, receiving ABT (160 or 320 mg) given weekly and LPV/r given twice daily. At week 7, the decline of HIV-1 RNA from baseline was 1.9 (1.3-2.3) log10 and 2.2 (1.6-2.7) log10 copies/ml, and suppression of HIV-1 RNA to below 50 copies/ml was achieved in 11.1 % (1/9) and 55.6 % (5/9) patients, for the 160 and 320 mg dose group respectively. A clear dose-efficacy correlation of ABT was demonstrated. ABT combining with LPV/r is a promising two-drug regimen to be tested in larger patient population. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 53 | 100% |
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Student > Master | 9 | 17% |
Researcher | 9 | 17% |
Student > Bachelor | 5 | 9% |
Other | 5 | 9% |
Student > Postgraduate | 4 | 8% |
Other | 11 | 21% |
Unknown | 10 | 19% |
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Pharmacology, Toxicology and Pharmaceutical Science | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
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Agricultural and Biological Sciences | 2 | 4% |
Other | 6 | 11% |
Unknown | 14 | 26% |