Title |
Differential gene expression in brain tissues of aggressive and non-aggressive dogs
|
---|---|
Published in |
BMC Veterinary Research, June 2010
|
DOI | 10.1186/1746-6148-6-34 |
Pubmed ID | |
Authors |
Jørn Våge, Tina B Bønsdorff, Ellen Arnet, Aage Tverdal, Frode Lingaas |
Abstract |
Canine behavioural problems, in particular aggression, are important reasons for euthanasia of otherwise healthy dogs. Aggressive behaviour in dogs also represents an animal welfare problem and a public threat. Elucidating the genetic background of adverse behaviour can provide valuable information to breeding programs and aid the development of drugs aimed at treating undesirable behaviour. With the intentions of identifying gene-specific expression in particular brain parts and comparing brains of aggressive and non-aggressive dogs, we studied amygdala, frontal cortex, hypothalamus and parietal cortex, as these tissues are reported to be involved in emotional reactions, including aggression. Based on quantitative real-time PCR (qRT-PCR) in 20 brains, obtained from 11 dogs euthanised because of aggressive behaviour and nine non-aggressive dogs, we studied expression of nine genes identified in an initial screening by subtraction hybridisation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 13% |
United States | 1 | 13% |
Norway | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | 1% |
Austria | 1 | 1% |
United Kingdom | 1 | 1% |
Singapore | 1 | 1% |
United States | 1 | 1% |
Unknown | 90 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 16% |
Student > Ph. D. Student | 14 | 15% |
Other | 12 | 13% |
Student > Bachelor | 12 | 13% |
Student > Master | 8 | 8% |
Other | 15 | 16% |
Unknown | 19 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 37 | 39% |
Medicine and Dentistry | 13 | 14% |
Veterinary Science and Veterinary Medicine | 10 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Psychology | 3 | 3% |
Other | 5 | 5% |
Unknown | 23 | 24% |