Title |
Monocytes conditioned media stimulate fibronectin expression and spreading of inflammatory breast cancer cells in three-dimensional culture: A mechanism mediated by IL-8 signaling pathway
|
---|---|
Published in |
Cell Communication and Signaling, February 2012
|
DOI | 10.1186/1478-811x-10-3 |
Pubmed ID | |
Authors |
Mona M Mohamed |
Abstract |
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer characterized by invasion of carcinoma cells into dermal lymphatic vessels where they form tumor emboli over expressing adhesion molecule E-cadherin. Although invasion and metastasis are dynamic processes controlled by complex interaction between tumor cells and microenvironment the mechanisms by which soluble mediators may regulate motility and invasion of IBC cells are poorly understood. The present study investigated the effect of media conditioned by human monocytes U937 secreted cytokines, chemokines and growth factors on the expression of adhesion molecules E-cadherin and fibronectin of human IBC cell line SUM149. Furthermore, cytokines signaling pathway involved were also identified. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 33% |
Chile | 1 | 17% |
South Africa | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Italy | 1 | 3% |
South Africa | 1 | 3% |
Unknown | 34 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 22% |
Researcher | 6 | 16% |
Student > Master | 4 | 11% |
Student > Doctoral Student | 3 | 8% |
Student > Bachelor | 2 | 5% |
Other | 8 | 22% |
Unknown | 6 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 38% |
Biochemistry, Genetics and Molecular Biology | 6 | 16% |
Medicine and Dentistry | 5 | 14% |
Immunology and Microbiology | 1 | 3% |
Unspecified | 1 | 3% |
Other | 2 | 5% |
Unknown | 8 | 22% |