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Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs

Overview of attention for article published in BMC Genomics, February 2016
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Title
Genome-wide DNA methylation profile of developing deciduous tooth germ in miniature pigs
Published in
BMC Genomics, February 2016
DOI 10.1186/s12864-016-2485-9
Pubmed ID
Authors

Yingying Su, Zhipeng Fan, Xiaoshan Wu, Yang Li, Fu Wang, Chunmei Zhang, Jinsong Wang, Jie Du, Songlin Wang

Abstract

DNA methylation is an important epigenetic modification critical to the regulation of gene expression during development. To date, little is known about the role of DNA methylation in tooth development in large animal models. Thus, we carried out a comparative genomic analysis of genome-wide DNA methylation profiles in E50 and E60 tooth germ from miniature pigs using methylated DNA immunoprecipitation-sequencing (MeDIP-seq). We observed different DNA methylation patterns during the different developmental stages of pig tooth germ. A total of 2469 differentially methylated genes were identified. Functional analysis identified several signaling pathways and 104 genes that may be potential key regulators of pig tooth development from E50 to E60. The present study provided a comprehensive analysis of the global DNA methylation pattern of tooth germ in miniature pigs and identified candidate genes that potentially regulate tooth development from E50 to E60.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 20%
Researcher 3 20%
Student > Doctoral Student 3 20%
Student > Master 2 13%
Other 1 7%
Other 1 7%
Unknown 2 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 33%
Medicine and Dentistry 3 20%
Nursing and Health Professions 1 7%
Veterinary Science and Veterinary Medicine 1 7%
Economics, Econometrics and Finance 1 7%
Other 1 7%
Unknown 3 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2016.
All research outputs
#18,616,159
of 23,881,329 outputs
Outputs from BMC Genomics
#7,812
of 10,793 outputs
Outputs of similar age
#206,622
of 301,365 outputs
Outputs of similar age from BMC Genomics
#189
of 234 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,793 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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We're also able to compare this research output to 234 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.