Title |
High-dose single-fraction IMRT versus fractionated external beam radiotherapy for patients with spinal bone metastases: study protocol for a randomized controlled trial
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Published in |
Trials, June 2015
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DOI | 10.1186/s13063-015-0761-7 |
Pubmed ID | |
Authors |
Harald Rief, Sonja Katayama, Thomas Bruckner, Stefan Rieken, Tilman Bostel, Robert Förster, Ingmar Schlampp, Robert Wolf, Jürgen Debus, Florian Sterzing |
Abstract |
Stereotactic body radiation therapy (SBRT)using intensity-modulated radiotherapy (IMRT) can be a safe modality for treating spinal bone metastasis with enhanced targeting accuracy and an effective method for achieving good tumor control and a rigorous pain response. This is a single-center, prospective randomized controlled trial to evaluate pain relief after RT and consists of two treatment groups with 30 patients in each group. One group will receive single-fraction intensity-modulated RT with 1×24 Gy, and the other will receive fractionated RT with 10×3 Gy. The target parameters will be measured at baseline and at 3 and 6 months after RT. The aim of this study is to evaluate pain relief after RT in patients with spinal bone metastases by means of two different techniques: stereotactic body radiation therapy and fractionated RT. The primary endpoint is pain relief at the 3-month time-point after RT. Secondly, quality of life, fatigue, overall and bone survival, and local control will be assessed. ClinicalTrials.gov identifier NCT02358720 (June 2, 2015). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 20% |
United Kingdom | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Scientists | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 2% |
Unknown | 57 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 17% |
Student > Master | 9 | 16% |
Student > Postgraduate | 6 | 10% |
Student > Ph. D. Student | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 10 | 17% |
Unknown | 14 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 43% |
Nursing and Health Professions | 5 | 9% |
Economics, Econometrics and Finance | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 7 | 12% |
Unknown | 17 | 29% |