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Progesterone acts via the progesterone receptor to induce adamts proteases in ovarian cancer cells

Overview of attention for article published in Journal of Ovarian Research, February 2016
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18 Mendeley
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Title
Progesterone acts via the progesterone receptor to induce adamts proteases in ovarian cancer cells
Published in
Journal of Ovarian Research, February 2016
DOI 10.1186/s13048-016-0219-x
Pubmed ID
Authors

Maíra A. Lima, Suély V. da Silva, Vanessa M. Freitas

Abstract

Ovarian carcinomas, usually associated with sex hormones dysregulation, are the leading cause of gynecological neoplastic death. In normal ovaries, hormones play a central role in regulating cell proliferation, differentiation, and apoptosis. On the other hand, hormonal alterations also play a variety of roles in cancer. Stimulation by sex hormones potentially affects gene expression, invasiveness, cell growth and angiogenesis. Proteases of the "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family are secreted by different cell types and become involved in collagen processing, cleavage of the proteoglycan matrix, and angiogenesis. We evaluated whether sex hormones affect ADAMTS 1 and 4 expression in ovarian cancer cells. We analysed mRNA and protein levels in human ovarian tumor cells with different degrees of malignancy, NIH-OVCAR-3 and ES-2, that were treated or not with estrogen, testosterone and progesterone. Our results suggest that progesterone increases ADAMTS protein and mRNA levels in the lysates from ES-2 cells, and it increases ADAMTS protein in the lysates and conditioned media from NIH-OVCAR-3. Progesterone effects were reversed by RU486 treatment. We conclude that progesterone acts via the progesterone receptor to modulate ADAMTS 1 and 4 levels in ovarian cancer cell lines.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 22%
Student > Bachelor 3 17%
Researcher 2 11%
Student > Master 2 11%
Student > Doctoral Student 1 6%
Other 3 17%
Unknown 3 17%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Agricultural and Biological Sciences 3 17%
Biochemistry, Genetics and Molecular Biology 1 6%
Chemical Engineering 1 6%
Immunology and Microbiology 1 6%
Other 1 6%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2016.
All research outputs
#5,508,080
of 7,295,661 outputs
Outputs from Journal of Ovarian Research
#86
of 151 outputs
Outputs of similar age
#198,353
of 282,649 outputs
Outputs of similar age from Journal of Ovarian Research
#7
of 13 outputs
Altmetric has tracked 7,295,661 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 151 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,649 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.