Title |
Stereotactic body radiotherapy (SBRT) for high-risk central pulmonary metastases
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Published in |
Radiation Oncology, February 2016
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DOI | 10.1186/s13014-016-0608-8 |
Pubmed ID | |
Authors |
Jonathan W. Lischalk, Ryan M. Malik, Sean P. Collins, Brian T. Collins, Ismael A. Matus, Eric D. Anderson |
Abstract |
Radiotherapy of central lung tumors carries a higher risk of treatment-related toxicity and local failure. In the era of aggressive oligometastic management the exploration of the proper dose-fractionation for metastatic central lung tumors is essential. Patients diagnosed with high-risk metastatic lesions of the central pulmonary tree comprised this single-institutional retrospective analysis. "High-risk" central pulmonary lesions were defined as those with abutment and/or invasion of the mainstem bronchus. All patients were treated using the CyberKnife SBRT system in 5 fractions to a total dose of 35 or 40 Gy. Twenty patients were treated from 2008 to 2011 at Georgetown University Hospital. At a median follow up of 19 months, 1-year Kaplan-Meier local control and overall survival was 70 and 75 %, respectively. Late grade 2 or higher atelectasis was the most common treatment-related toxicity and was significantly associated with maximum dose to the mainstem bronchus. Gross endobronchial involvement was associated with significantly lower overall survival. Five-fraction SBRT to a total dose of 35 or 40 Gy appears to be a safe and effective management strategy for high-risk central pulmonary metastatic lesions, though care should be taken to limit the maximum point dose to the mainstem bronchus. |
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Italy | 1 | 33% |
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Cyprus | 1 | 33% |
Demographic breakdown
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Mendeley readers
Geographical breakdown
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Unknown | 51 | 100% |
Demographic breakdown
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Researcher | 8 | 16% |
Student > Master | 7 | 14% |
Student > Postgraduate | 5 | 10% |
Student > Bachelor | 4 | 8% |
Other | 8 | 16% |
Unknown | 11 | 22% |
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Chemistry | 1 | 2% |
Other | 1 | 2% |
Unknown | 16 | 31% |