Title |
PhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae
|
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Published in |
BMC Genomics, December 2011
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DOI | 10.1186/1471-2164-12-614 |
Pubmed ID | |
Authors |
Antonio Palmeri, Pier Federico Gherardini, Polina Tsigankov, Gabriele Ausiello, Gerald F Späth, Dan Zilberstein, Manuela Helmer-Citterich |
Abstract |
Protein phosphorylation modulates protein function in organisms at all levels of complexity. Parasites of the Leishmania genus undergo various developmental transitions in their life cycle triggered by changes in the environment. The molecular mechanisms that these organisms use to process and integrate these external cues are largely unknown. However Leishmania lacks transcription factors, therefore most regulatory processes may occur at a post-translational level and phosphorylation has recently been demonstrated to be an important player in this process. Experimental identification of phosphorylation sites is a time-consuming task. Moreover some sites could be missed due to the highly dynamic nature of this process or to difficulties in phospho-peptide enrichment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
India | 1 | 2% |
Germany | 1 | 2% |
Unknown | 39 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 19% |
Student > Ph. D. Student | 7 | 17% |
Student > Master | 6 | 14% |
Student > Bachelor | 3 | 7% |
Professor > Associate Professor | 3 | 7% |
Other | 7 | 17% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 38% |
Biochemistry, Genetics and Molecular Biology | 8 | 19% |
Immunology and Microbiology | 3 | 7% |
Chemistry | 2 | 5% |
Computer Science | 2 | 5% |
Other | 3 | 7% |
Unknown | 8 | 19% |