Title |
P2X7 Receptors in Satellite Glial Cells Mediate High Functional Expression of P2X3 Receptors in Immature Dorsal Root Ganglion Neurons
|
---|---|
Published in |
Molecular Pain, January 2012
|
DOI | 10.1186/1744-8069-8-9 |
Pubmed ID | |
Authors |
Yong Chen, Guangwen Li, Li-Yen Mae Huang |
Abstract |
The purinergic P2X3 receptor (P2X3R) expressed in the dorsal root ganglion (DRG) sensory neuron and the P2X7 receptor (P2X7R) expressed in the surrounding satellite glial cell (SGC) are two major receptors participating in neuron-SGC communication in adult DRGs. Activation of P2X7Rs was found to tonically reduce the expression of P2X3Rs in DRGs, thus inhibiting the abnormal pain behaviors in adult rats. P2X receptors are also actively involved in sensory signaling in developing rodents. However, very little is known about the developmental change of P2X7Rs in DRGs and the interaction between P2X7Rs and P2X3Rs in those animals. We therefore examined the expression of P2X3Rs and P2X7Rs in postnatal rats and determined if P2X7R-P2X3R control exists in developing rats. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Spain | 1 | <1% |
Italy | 1 | <1% |
Romania | 1 | <1% |
Unknown | 182 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 18% |
Researcher | 26 | 14% |
Student > Master | 18 | 10% |
Student > Bachelor | 14 | 8% |
Student > Doctoral Student | 11 | 6% |
Other | 30 | 16% |
Unknown | 54 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 41 | 22% |
Agricultural and Biological Sciences | 25 | 13% |
Medicine and Dentistry | 18 | 10% |
Biochemistry, Genetics and Molecular Biology | 13 | 7% |
Nursing and Health Professions | 6 | 3% |
Other | 25 | 13% |
Unknown | 58 | 31% |