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P2X7 Receptors in Satellite Glial Cells Mediate High Functional Expression of P2X3 Receptors in Immature Dorsal Root Ganglion Neurons

Overview of attention for article published in Molecular Pain, January 2012
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186 Mendeley
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Title
P2X7 Receptors in Satellite Glial Cells Mediate High Functional Expression of P2X3 Receptors in Immature Dorsal Root Ganglion Neurons
Published in
Molecular Pain, January 2012
DOI 10.1186/1744-8069-8-9
Pubmed ID
Authors

Yong Chen, Guangwen Li, Li-Yen Mae Huang

Abstract

The purinergic P2X3 receptor (P2X3R) expressed in the dorsal root ganglion (DRG) sensory neuron and the P2X7 receptor (P2X7R) expressed in the surrounding satellite glial cell (SGC) are two major receptors participating in neuron-SGC communication in adult DRGs. Activation of P2X7Rs was found to tonically reduce the expression of P2X3Rs in DRGs, thus inhibiting the abnormal pain behaviors in adult rats. P2X receptors are also actively involved in sensory signaling in developing rodents. However, very little is known about the developmental change of P2X7Rs in DRGs and the interaction between P2X7Rs and P2X3Rs in those animals. We therefore examined the expression of P2X3Rs and P2X7Rs in postnatal rats and determined if P2X7R-P2X3R control exists in developing rats.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Spain 1 <1%
Italy 1 <1%
Romania 1 <1%
Unknown 182 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 18%
Researcher 26 14%
Student > Master 18 10%
Student > Bachelor 14 8%
Student > Doctoral Student 11 6%
Other 30 16%
Unknown 54 29%
Readers by discipline Count As %
Neuroscience 41 22%
Agricultural and Biological Sciences 25 13%
Medicine and Dentistry 18 10%
Biochemistry, Genetics and Molecular Biology 13 7%
Nursing and Health Professions 6 3%
Other 25 13%
Unknown 58 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2012.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Molecular Pain
#595
of 669 outputs
Outputs of similar age
#228,476
of 250,087 outputs
Outputs of similar age from Molecular Pain
#44
of 47 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,087 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.