Title |
Comorbid epilepsy in Finnish patients with adult-onset Huntington’s disease
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Published in |
BMC Neurology, February 2016
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DOI | 10.1186/s12883-016-0545-z |
Pubmed ID | |
Authors |
Jussi O. T. Sipilä, Merja Soilu-Hänninen, Kari Majamaa |
Abstract |
Seizures are common in juvenile Huntington's disease (HD), but considered to be rare in adult-onset HD. We studied the occurrence of epilepsy and seizures in a nationwide cohort of Finnish patients with adult-onset HD. Patients with HD and their diagnoses of epilepsy or seizures were identified by a search into a nationwide registry. Cases were verified in a subsequent review of patient charts. Three out of 114 HD patients alive on prevalence date had been diagnosed with epilepsy giving a prevalence of 2.6 % (95 % CI, 0.6-7.5). In addition, one patient with a single unprovoked seizure, one patient with a medication-induced seizure and two patients with transient nonspecific attacks were identified. Epilepsy was not associated with clinical severity of HD and seizures were controlled with antiepileptic medications (AEDs). Generalized tonic-clonic seizures (GTCs) were the most common seizure type. Prevalence of epilepsy is similar in patients with adult-onset HD compared to general population. Seizures are easily controlled with AEDs. |
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Demographic breakdown
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Student > Bachelor | 6 | 17% |
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Agricultural and Biological Sciences | 2 | 6% |
Other | 5 | 14% |
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