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Mendeley readers
Attention Score in Context
| Title |
Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity
|
|---|---|
| Published in |
Molecular Brain, February 2012
|
| DOI | 10.1186/1756-6606-5-8 |
| Pubmed ID | |
| Authors |
Masanori Nomoto, Yohei Takeda, Shusaku Uchida, Koji Mitsuda, Hatsune Enomoto, Kaori Saito, Tesu Choi, Ayako M Watabe, Shizuka Kobayashi, Shoichi Masushige, Toshiya Manabe, Satoshi Kida |
| Abstract |
Retinoid signaling pathways mediated by retinoic acid receptor (RAR)/retinoid × receptor (RXR)-mediated transcription play critical roles in hippocampal synaptic plasticity. Furthermore, recent studies have shown that treatment with retinoic acid alleviates age-related deficits in hippocampal long-term potentiation (LTP) and memory performance and, furthermore, memory deficits in a transgenic mouse model of Alzheimer's disease. However, the roles of the RAR/RXR signaling pathway in learning and memory at the behavioral level have still not been well characterized in the adult brain. We here show essential roles for RAR/RXR in hippocampus-dependent learning and memory. In the current study, we generated transgenic mice in which the expression of dominant-negative RAR (dnRAR) could be induced in the mature brain using a tetracycline-dependent transcription factor and examined the effects of RAR/RXR loss. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 50% |
| Members of the public | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| Unknown | 102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 24% |
| Researcher | 15 | 15% |
| Student > Bachelor | 15 | 15% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 4 | 4% |
| Other | 14 | 14% |
| Unknown | 21 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 20% |
| Neuroscience | 21 | 20% |
| Biochemistry, Genetics and Molecular Biology | 11 | 11% |
| Medicine and Dentistry | 8 | 8% |
| Psychology | 3 | 3% |
| Other | 15 | 15% |
| Unknown | 24 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2022.
All research outputs
#13,101,532
of 23,426,104 outputs
Outputs from Molecular Brain
#405
of 1,137 outputs
Outputs of similar age
#144,373
of 250,780 outputs
Outputs of similar age from Molecular Brain
#9
of 14 outputs
Altmetric has tracked 23,426,104 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,137 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,780 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.