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A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats

Overview of attention for article published in Biological Research, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#40 of 642)
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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1 blog
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114 Mendeley
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Title
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats
Published in
Biological Research, February 2016
DOI 10.1186/s40659-016-0075-6
Pubmed ID
Authors

Cuauhtemoc Sandoval-Salazar, Joel Ramírez-Emiliano, Aurora Trejo-Bahena, Cecilia I. Oviedo-Solís, Martha Silvia Solís-Ortiz

Abstract

It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats. The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats. HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 114 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 17%
Student > Master 17 15%
Student > Ph. D. Student 16 14%
Student > Bachelor 12 11%
Professor 9 8%
Other 18 16%
Unknown 23 20%
Readers by discipline Count As %
Neuroscience 26 23%
Biochemistry, Genetics and Molecular Biology 15 13%
Nursing and Health Professions 11 10%
Agricultural and Biological Sciences 9 8%
Medicine and Dentistry 8 7%
Other 18 16%
Unknown 27 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2018.
All research outputs
#4,168,596
of 25,374,917 outputs
Outputs from Biological Research
#40
of 642 outputs
Outputs of similar age
#60,417
of 312,040 outputs
Outputs of similar age from Biological Research
#4
of 19 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 642 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,040 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.