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Mendeley readers
Attention Score in Context
| Title |
The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers
|
|---|---|
| Published in |
BMC Neuroscience, September 2009
|
| DOI | 10.1186/1471-2202-10-125 |
| Pubmed ID | |
| Authors |
Manuel Fernández Martínez, Xabier Elcoroaristizabal Martín, Luís Galdos Alcelay, Jessica Castro Flores, Juan María Uterga Valiente, Begoña Indakoetxea Juanbeltz, María Ángeles Gómez Beldarraín, Josefa Moraza López, María Carmen Gonzalez-Fernández, Ana Molano Salazar, Rocio Bereincua Gandarias, Sandra Inglés Borda, Nuria Ortiz Marqués, Miryam Barandiarán Amillano, María Carrasco Zabaleta, Marian M de Pancorbo |
| Abstract |
The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic type (MCI), and its synergistic effect with the apolipoprotein E gene (APOE).A total of 223 MCI patients, 345 AD and 253 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups.The DNA Bank of the University of the Basque Country (UPV-EHU) (Spain) determined COMT Val158 Met and APOE genotypes using real time polymerase chain reaction (rtPCR) and polymerase chain reaction (PCR), and restriction fragment length polymorphism (RFLPs), respectively. Multinomial logistic regression models were used to determine the risk of AD and MCI. |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 83 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 18% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Master | 10 | 12% |
| Student > Doctoral Student | 9 | 11% |
| Other | 8 | 10% |
| Other | 15 | 18% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 20% |
| Psychology | 12 | 14% |
| Agricultural and Biological Sciences | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Neuroscience | 7 | 8% |
| Other | 9 | 11% |
| Unknown | 20 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2011.
All research outputs
#20,155,513
of 22,663,150 outputs
Outputs from BMC Neuroscience
#1,050
of 1,240 outputs
Outputs of similar age
#88,736
of 92,744 outputs
Outputs of similar age from BMC Neuroscience
#15
of 15 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,744 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.