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Effect of tDCS with an extracephalic reference electrode on cardio-respiratory and autonomic functions

Overview of attention for article published in BMC Neuroscience, March 2010
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Title
Effect of tDCS with an extracephalic reference electrode on cardio-respiratory and autonomic functions
Published in
BMC Neuroscience, March 2010
DOI 10.1186/1471-2202-11-38
Pubmed ID
Authors

Yves Vandermeeren, Jacques Jamart, Michel Ossemann

Abstract

Transcranial direct current stimulation (tDCS) is used in human physiological studies and for therapeutic trials in patients with abnormalities of cortical excitability. Its safety profile places tDCS in the pole-position for translating in real-world therapeutic application. However, an episode of transient respiratory depression in a subject receiving tDCS with an extracephalic electrode led to the suggestion that such an electrode montage could modulate the brainstem autonomic centres. We investigated whether tDCS applied over the midline frontal cortex in 30 healthy volunteers (sham n = 10, cathodal n = 10, anodal n = 10) with an extracephalic reference electrode would modulate brainstem activity as reflected by the monitoring and stringent analysis of vital parameters: heart rate (variability), respiratory rate, blood pressure and sympatho-vagal balance. We reasoned that this study could lead to two opposite but equally interesting outcomes: 1) If tDCS with an extracephalic electrode modulated vital parameters, it could be used as a new tool to explore the autonomic nervous system and, even, to modulate its activity for therapeutic purposes. 2) On the opposite, if applying tDCS with an extracephalic electrode had no effect, it could thus be used safely in healthy human subjects. This outcome would significantly impact the field of non-invasive brain stimulation with tDCS. Indeed, on the one hand, using an extracephalic electrode as a genuine neutral reference (as opposed to the classical "bi-cephalic" tDCS montages which deliver bi-polar stimulation of the brain) would help to comfort the conclusions of several modern studies regarding the spatial location and polarity of tDCS. On the other hand, using an extracephalic reference electrode may impact differently on a given cortical target due to the change of direct current flow direction; this may enlarge the potential interventions with tDCS.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 4 2%
United States 4 2%
Germany 3 1%
United Kingdom 2 <1%
Iran, Islamic Republic of 2 <1%
Brazil 1 <1%
Canada 1 <1%
Switzerland 1 <1%
New Zealand 1 <1%
Other 2 <1%
Unknown 226 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 20%
Researcher 45 18%
Student > Master 25 10%
Student > Bachelor 18 7%
Student > Postgraduate 17 7%
Other 53 21%
Unknown 39 16%
Readers by discipline Count As %
Psychology 57 23%
Medicine and Dentistry 40 16%
Neuroscience 35 14%
Engineering 16 6%
Agricultural and Biological Sciences 12 5%
Other 34 14%
Unknown 53 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2013.
All research outputs
#21,652,714
of 24,167,226 outputs
Outputs from BMC Neuroscience
#1,078
of 1,269 outputs
Outputs of similar age
#93,097
of 97,333 outputs
Outputs of similar age from BMC Neuroscience
#17
of 19 outputs
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.