Title |
BLANNOTATOR: enhanced homology-based function prediction of bacterial proteins
|
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Published in |
BMC Bioinformatics, February 2012
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DOI | 10.1186/1471-2105-13-33 |
Pubmed ID | |
Authors |
Matti Kankainen, Teija Ojala, Liisa Holm |
Abstract |
Automated function prediction has played a central role in determining the biological functions of bacterial proteins. Typically, protein function annotation relies on homology, and function is inferred from other proteins with similar sequences. This approach has become popular in bacterial genomics because it is one of the few methods that is practical for large datasets and because it does not require additional functional genomics experiments. However, the existing solutions produce erroneous predictions in many cases, especially when query sequences have low levels of identity with the annotated source protein. This problem has created a pressing need for improvements in homology-based annotation. |
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Geographical breakdown
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Germany | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | 2% |
Sweden | 1 | 2% |
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Denmark | 1 | 2% |
Unknown | 51 | 82% |
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Student > Ph. D. Student | 10 | 16% |
Student > Master | 8 | 13% |
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Student > Doctoral Student | 4 | 6% |
Other | 12 | 19% |
Unknown | 5 | 8% |
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Immunology and Microbiology | 1 | 2% |
Other | 2 | 3% |
Unknown | 5 | 8% |