Title |
Inhibition of CD26/DPP-IV enhances donor muscle cell engraftment and stimulates sustained donor cell proliferation
|
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Published in |
Skeletal Muscle, February 2012
|
DOI | 10.1186/2044-5040-2-4 |
Pubmed ID | |
Authors |
Maura H Parker, Carol Loretz, Ashlee E Tyler, Lauren Snider, Rainer Storb, Stephen J Tapscott |
Abstract |
Transplantation of myogenic stem cells possesses great potential for long-term repair of dystrophic muscle. In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx5cv mice. Together, these data suggest that CXCR4 plays an important role in donor cell engraftment. Therefore, we sought to translate these results to a clinically relevant canine-to-canine allogeneic transplant model for Duchenne muscular dystrophy (DMD) and determine if CXCR4 is important for donor cell engraftment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 5% |
Netherlands | 1 | 5% |
Brazil | 1 | 5% |
Unknown | 16 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 21% |
Student > Doctoral Student | 2 | 11% |
Student > Bachelor | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Professor | 1 | 5% |
Other | 3 | 16% |
Unknown | 5 | 26% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Social Sciences | 1 | 5% |
Decision Sciences | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 32% |