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Mendeley readers
| Title |
Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells
|
|---|---|
| Published in |
Particle and Fibre Toxicology, February 2012
|
| DOI | 10.1186/1743-8977-9-6 |
| Pubmed ID | |
| Authors |
Timothy N Perkins, Arti Shukla, Paul M Peeters, Jeremy L Steinbacher, Christopher C Landry, Sherrill A Lathrop, Chad Steele, Niki L Reynaert, Emiel FM Wouters, Brooke T Mossman |
| Abstract |
Exposure to respirable crystalline silica particles, as opposed to amorphous silica, is associated with lung inflammation, pulmonary fibrosis (silicosis), and potentially with lung cancer. We used Affymetrix/GeneSifter microarray analysis to determine whether gene expression profiles differed in a human bronchial epithelial cell line (BEAS 2B) exposed to cristobalite vs. amorphous silica particles at non-toxic and equal surface areas (75 and 150 × 106μm2/cm2). Bio-Plex analysis was also used to determine profiles of secreted cytokines and chemokines in response to both particles. Finally, primary human bronchial epithelial cells (NHBE) were used to comparatively assess silica particle-induced alterations in gene expression. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 1% |
| Germany | 1 | 1% |
| United Kingdom | 1 | 1% |
| Canada | 1 | 1% |
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 63 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 22% |
| Student > Master | 11 | 16% |
| Researcher | 8 | 12% |
| Other | 6 | 9% |
| Professor > Associate Professor | 5 | 7% |
| Other | 12 | 17% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 32% |
| Medicine and Dentistry | 10 | 14% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Immunology and Microbiology | 5 | 7% |
| Chemistry | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 14 | 20% |