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Alzheimer's disease - input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial

Overview of attention for article published in Trials, October 2011
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Title
Alzheimer's disease - input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial
Published in
Trials, October 2011
DOI 10.1186/1745-6215-12-230
Pubmed ID
Authors

Cédric Annweiler, Bruno Fantino, Elsa Parot-Schinkel, Samuel Thiery, Jennifer Gautier, Olivier Beauchet

Abstract

Current treatments for Alzheimer's disease and related disorders (ADRD) are symptomatic and can only temporarily slow down ADRD. Future possibilities of care rely on multi-target drugs therapies that address simultaneously several pathophysiological processes leading to neurodegeneration. We hypothesized that the combination of memantine with vitamin D could be neuroprotective in ADRD, thereby limiting neuronal loss and cognitive decline. The aim of this trial is to compare the effect after 24 weeks of the oral intake of vitamin D3 (cholecalciferol) with the effect of a placebo on the change of cognitive performance in patients suffering from moderate ADRD and receiving memantine.

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Mendeley readers

The data shown below were compiled from readership statistics for 295 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Netherlands 1 <1%
Portugal 1 <1%
Unknown 292 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 43 15%
Researcher 33 11%
Student > Bachelor 33 11%
Student > Ph. D. Student 29 10%
Student > Postgraduate 18 6%
Other 65 22%
Unknown 74 25%
Readers by discipline Count As %
Medicine and Dentistry 73 25%
Nursing and Health Professions 28 9%
Psychology 24 8%
Agricultural and Biological Sciences 17 6%
Social Sciences 15 5%
Other 49 17%
Unknown 89 30%