Title |
Alzheimer's disease - input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial
|
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Published in |
Trials, October 2011
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DOI | 10.1186/1745-6215-12-230 |
Pubmed ID | |
Authors |
Cédric Annweiler, Bruno Fantino, Elsa Parot-Schinkel, Samuel Thiery, Jennifer Gautier, Olivier Beauchet |
Abstract |
Current treatments for Alzheimer's disease and related disorders (ADRD) are symptomatic and can only temporarily slow down ADRD. Future possibilities of care rely on multi-target drugs therapies that address simultaneously several pathophysiological processes leading to neurodegeneration. We hypothesized that the combination of memantine with vitamin D could be neuroprotective in ADRD, thereby limiting neuronal loss and cognitive decline. The aim of this trial is to compare the effect after 24 weeks of the oral intake of vitamin D3 (cholecalciferol) with the effect of a placebo on the change of cognitive performance in patients suffering from moderate ADRD and receiving memantine. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Netherlands | 1 | <1% |
Portugal | 1 | <1% |
Unknown | 292 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 43 | 15% |
Researcher | 33 | 11% |
Student > Bachelor | 33 | 11% |
Student > Ph. D. Student | 29 | 10% |
Student > Postgraduate | 18 | 6% |
Other | 65 | 22% |
Unknown | 74 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 73 | 25% |
Nursing and Health Professions | 28 | 9% |
Psychology | 24 | 8% |
Agricultural and Biological Sciences | 17 | 6% |
Social Sciences | 15 | 5% |
Other | 49 | 17% |
Unknown | 89 | 30% |