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Mendeley readers
| Title |
Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
|
|---|---|
| Published in |
Journal of Hematology & Oncology, July 2015
|
| DOI | 10.1186/s13045-015-0191-8 |
| Pubmed ID | |
| Authors |
Kerice A. Pinkney, Wenxia Jiang, Brian J. Lee, Denis G. Loredan, Chen Li, Govind Bhagat, Shan Zha |
| Abstract |
Bcl11b is a transcription factor important for T cell development and also a tumor-suppressor gene that is hemizygously inactivated in ~10 % human T cell acute lymphoblastic leukemia (T-ALL) and several murine T-ALL models, including ATM(-/-) thymic lymphomas. Here we report that heterozygous loss of Bcl11b (Bcl11b(+/-)) unexpectedly reduced lethal thymic lymphoma in ATM(-/-) mice by suppressing lymphoma progression, but not initiation. The suppression was associated with a T cell-mediated immune response in ATM(-/-)Bcl11b(+/-) mice, revealing a haploid insufficient function of Bcl11b in immune modulation against lymphoma and offering an explanation for the complex relationship between Bcl11b status with T-ALL prognosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 25% |
| Professor | 2 | 17% |
| Other | 2 | 17% |
| Student > Master | 2 | 17% |
| Professor > Associate Professor | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 2 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 33% |
| Immunology and Microbiology | 3 | 25% |
| Agricultural and Biological Sciences | 1 | 8% |
| Arts and Humanities | 1 | 8% |
| Medicine and Dentistry | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 1 | 8% |