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Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial

Overview of attention for article published in Trials, March 2016
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Title
Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial
Published in
Trials, March 2016
DOI 10.1186/s13063-016-1230-7
Pubmed ID
Authors

Kate E. A. Saunders, Andrea Cipriani, Jennifer Rendell, Mary-Jane Attenburrow, Natalie Nelissen, Amy C. Bilderbeck, Sridhar R. Vasudevan, Grant Churchill, Guy M. Goodwin, Anna C. Nobre, Catherine J. Harmer, Paul J. Harrison, John R. Geddes

Abstract

Despite lithium's being the most effective drug for bipolar disorder and in clinical use for decades, we still know very little about its early effects relevant to its mode of action. The Oxford Lithium Trial is a double-blind, randomised, placebo-controlled study of 6-week lithium treatment in participants with bipolar disorder and mood instability. Its aim is to identify early clinical, neurocognitive and biological effects. Participants (nā€‰=ā€‰40) will undergo an intensive battery of multi-modal investigations, including remote monitoring of mood, activity and physiology, as well as cognitive testing, fMRI and magnetoencephalography, together with biochemical and gene expression measurements to assess renal, inflammatory and circadian effects. The findings derived from this trial may be of value in predicting subsequent therapeutic response or side effects, not only relevant to the use of lithium but also providing a potential signature to help in more rapid evaluation of novel mood stabilisers. In this respect, OxLith is a step towards the development of a valid experimental medicine model for bipolar disorder. ISRCTN91624955 . Registered on 22 January 2015.

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Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Unknown 125 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 16%
Student > Master 19 15%
Student > Bachelor 19 15%
Student > Postgraduate 9 7%
Student > Ph. D. Student 7 6%
Other 21 17%
Unknown 32 25%
Readers by discipline Count As %
Psychology 30 24%
Medicine and Dentistry 27 21%
Nursing and Health Professions 8 6%
Neuroscience 7 6%
Biochemistry, Genetics and Molecular Biology 5 4%
Other 12 9%
Unknown 38 30%