Title |
Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis
|
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Published in |
Respiratory Research, March 2016
|
DOI | 10.1186/s12931-016-0343-6 |
Pubmed ID | |
Authors |
Annie Pardo, Sandra Cabrera, Mariel Maldonado, Moisés Selman |
Abstract |
Idiopathic pulmonary fibrosis (IPF) is a progressive and devastating lung disorder of unknown origin, with very poor prognosis and no effective treatment. The disease is characterized by abnormal activation of alveolar epithelial cells, which secrete numerous mediators involved in the expansion of the fibroblast population, its differentiation to myofibroblasts, and in the exaggerated accumulation of extracellular matrix provoking the loss of lung architecture. Among the excessively produced mediators are several matrix metalloproteases (MMPs) which may contribute to modify the lung microenvironment by various mechanisms. Thus, these enzymes can not only degrade all the components of the extracellular matrix, but they are also able to release, cleave and activate a wide range of growth factors, cytokines, chemokines and cell surface receptors affecting numerous cell functions including adhesion, proliferation, differentiation, recruiting and transmigration, and apoptosis. Therefore, dysregulated expression of MMPs may have profound impact on the biopathological mechanisms implicated in the development of IPF. This review focuses on the current and emerging evidence regarding the role of MMPs on the fibrotic processes in IPF as well as in mouse models of lung fibrosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 20% |
United States | 1 | 10% |
Israel | 1 | 10% |
Ireland | 1 | 10% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 70% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Scientists | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 202 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 36 | 18% |
Researcher | 25 | 12% |
Student > Bachelor | 24 | 12% |
Student > Master | 21 | 10% |
Student > Doctoral Student | 10 | 5% |
Other | 34 | 17% |
Unknown | 54 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 45 | 22% |
Medicine and Dentistry | 41 | 20% |
Agricultural and Biological Sciences | 18 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
Immunology and Microbiology | 10 | 5% |
Other | 20 | 10% |
Unknown | 60 | 29% |