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Mendeley readers
| Title |
Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum
|
|---|---|
| Published in |
Malaria Journal, February 2012
|
| DOI | 10.1186/1475-2875-11-45 |
| Pubmed ID | |
| Authors |
Aurélie Pascual, Philippe Parola, Françoise Benoit-Vical, Fabrice Simon, Denis Malvy, Stéphane Picot, Pascal Delaunay, Didier Basset, Danièle Maubon, Bernard Faugère, Guillaume Ménard, Nathalie Bourgeois, Claude Oeuvray, Eric Didillon, Christophe Rogier, Bruno Pradines |
| Abstract |
The aim of the present work was to assess i) ex vivo activity of pyronaridine (PND) and piperaquine (PPQ), as new components of artemisinin-based combination therapy (ACT), to define susceptibility baseline, ii) their activities compared to other partner drugs, namely monodesethylamodiaquine (MDAQ), lumefantrine (LMF), mefloquine (MQ), artesunate (AS) and dihydroartemisinin (DHA) against 181 Plasmodium falciparum isolates from African countries, India and Thailand, and iii) in vitro cross-resistance with other quinoline drugs, chloroquine (CQ) or quinine (QN). |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| Mexico | 1 | 2% |
| Unknown | 45 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 15% |
| Student > Ph. D. Student | 6 | 13% |
| Student > Master | 6 | 13% |
| Student > Bachelor | 6 | 13% |
| Professor > Associate Professor | 5 | 10% |
| Other | 16 | 33% |
| Unknown | 2 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 35% |
| Agricultural and Biological Sciences | 8 | 17% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Chemistry | 5 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 7 | 15% |
| Unknown | 4 | 8% |