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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice
|
|---|---|
| Published in |
Journal of Neurodevelopmental Disorders, March 2016
|
| DOI | 10.1186/s11689-016-9140-2 |
| Pubmed ID | |
| Authors |
Remco T. Molenhuis, Hilgo Bruining, Esther Remmelink, Leonie de Visser, Maarten Loos, J. Peter H. Burbach, Martien J. H. Kas |
| Abstract |
Mouse models offer an essential tool to unravel the impact of genetic mutations on autism-related phenotypes. The behavioral impact of some important candidate gene models for autism spectrum disorder (ASD) has not yet been studied, and existing characterizations mostly describe behavioral phenotypes at adult ages, disregarding the developmental nature of the disorder. In this context, the behavioral influence of CNTN4, one of the strongest suggested ASD candidate genes, is unknown. Here, we used our recently established developmental test battery to characterize the consequences of disruption of contactin 4 (Cntn4) on neurological, sensory, cognitive, and behavioral phenotypes across different developmental stages. C57BL/6J mice with heterozygous and homozygous disruption of Cntn4 were studied through an extensive, partially longitudinal, test battery at various developmental stages, including various paradigms testing social and restricted repetitive behaviors. Developmental neurological and cognitive screenings revealed no significant differences between genotypes, and ASD-related behavioral domains were also unchanged in Cntn4-deficient versus wild-type mice. The impact of Cntn4-deficiency was found to be limited to increased startle responsiveness following auditory stimuli of different high amplitudes in heterozygous and homozygous Cntn4-deficient mice and enhanced acquisition in a spatial learning task in homozygous mice. Disruption of Cntn4 in the C57BL/6J background does not affect specific autism-related phenotypes in developing or adult mice but causes subtle non-disorder specific changes in sensory behavioral responses and cognitive performance. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 25% |
| Canada | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 83 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 20% |
| Researcher | 14 | 17% |
| Student > Master | 14 | 17% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Doctoral Student | 6 | 7% |
| Other | 7 | 8% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 17% |
| Agricultural and Biological Sciences | 11 | 13% |
| Psychology | 10 | 12% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Medicine and Dentistry | 9 | 11% |
| Other | 11 | 13% |
| Unknown | 20 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2016.
All research outputs
#14,899,554
of 25,556,408 outputs
Outputs from Journal of Neurodevelopmental Disorders
#333
of 513 outputs
Outputs of similar age
#150,063
of 313,243 outputs
Outputs of similar age from Journal of Neurodevelopmental Disorders
#7
of 9 outputs
Altmetric has tracked 25,556,408 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 513 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,243 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.