Title |
Plasmodium falciparum: multifaceted resistance to artemisinins
|
---|---|
Published in |
Malaria Journal, March 2016
|
DOI | 10.1186/s12936-016-1206-9 |
Pubmed ID | |
Authors |
Lucie Paloque, Arba P. Ramadani, Odile Mercereau-Puijalon, Jean-Michel Augereau, Françoise Benoit-Vical |
Abstract |
Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation of the PfK13 propeller domain and involves an unconventional mechanism based on a quiescence state leading to parasite recrudescence as soon as drug pressure is removed. The enhanced P. falciparum quiescence capacity of artemisinin-resistant parasites results from an increased ability to manage oxidative damage and an altered cell cycle gene regulation within a complex network involving the unfolded protein response, the PI3K/PI3P/AKT pathway, the PfPK4/eIF2α cascade and yet unidentified transcription factor(s), with minimal energetic requirements and fatty acid metabolism maintained in the mitochondrion and apicoplast. The detailed study of these mechanisms offers a way forward for identifying future intervention targets to fend off established artemisinin resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 13% |
Japan | 1 | 13% |
Poland | 1 | 13% |
Italy | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 4 | 50% |
Members of the public | 3 | 38% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Nigeria | 1 | <1% |
Unknown | 307 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 55 | 18% |
Student > Master | 54 | 18% |
Student > Bachelor | 37 | 12% |
Researcher | 31 | 10% |
Student > Doctoral Student | 20 | 6% |
Other | 51 | 17% |
Unknown | 60 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 83 | 27% |
Agricultural and Biological Sciences | 39 | 13% |
Medicine and Dentistry | 29 | 9% |
Chemistry | 26 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 25 | 8% |
Other | 39 | 13% |
Unknown | 67 | 22% |