Title |
GABA and glycine in the developing brain
|
---|---|
Published in |
The Journal of Physiological Sciences, March 2016
|
DOI | 10.1007/s12576-016-0442-7 |
Pubmed ID | |
Authors |
Susumu Ito |
Abstract |
GABA and glycine are major inhibitory neurotransmitters in the CNS and act on receptors coupled to chloride channels. During early developmental periods, both GABA and glycine depolarize membrane potentials due to the relatively high intracellular Cl(-) concentration. Therefore, they can act as excitatory neurotransmitters. GABA and glycine are involved in spontaneous neural network activities in the immature CNS such as giant depolarizing potentials (GDPs) in neonatal hippocampal neurons, which are generated by the synchronous activity of GABAergic interneurons and glutamatergic principal neurons. GDPs and GDP-like activities in the developing brains are thought to be important for the activity-dependent functiogenesis through Ca(2+) influx and/or other intracellular signaling pathways activated by depolarization or stimulation of metabotropic receptors. However, if GABA and glycine do not shift from excitatory to inhibitory neurotransmitters at the birth and in maturation, it may result in neural disorders including autism spectrum disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
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Brazil | 1 | 1% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 18% |
Student > Master | 13 | 16% |
Student > Bachelor | 12 | 15% |
Student > Doctoral Student | 6 | 8% |
Researcher | 5 | 6% |
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Medicine and Dentistry | 4 | 5% |
Other | 8 | 10% |
Unknown | 22 | 28% |