Title |
A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia
|
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Published in |
BMC Musculoskeletal Disorders, February 2012
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DOI | 10.1186/1471-2474-13-23 |
Pubmed ID | |
Authors |
Gilberto Vargas-Alarcon, Edith Alvarez-Leon, Jose-Manuel Fragoso, Angelica Vargas, Aline Martinez, Maite Vallejo, Manuel Martinez-Lavin |
Abstract |
A consistent line of investigation suggests that autonomic nervous system dysfunction may explain the multi-system features of fibromyalgia (FM); and that FM is a sympathetically maintained neuropathic pain syndrome. Dorsal root ganglia (DRG) are key sympathetic-nociceptive short-circuit sites. Sodium channels located in DRG (particularly Nav1.7) act as molecular gatekeepers for pain detection. Nav1.7 is encoded in gene SCN9A of chromosome 2q24.3 and is predominantly expressed in the DRG pain-sensing neurons and sympathetic ganglia neurons. Several SCN9A sodium channelopathies have been recognized as the cause of rare painful dysautonomic syndromes such as paroxysmal extreme pain disorder and primary erythromelalgia. The aim of this study was to search for an association between fibromyalgia and several SCN9A sodium channels gene polymorphisms. |
X Demographics
Geographical breakdown
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United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 25% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 1% |
Australia | 1 | 1% |
Unknown | 94 | 97% |
Demographic breakdown
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Student > Master | 16 | 16% |
Student > Bachelor | 13 | 13% |
Student > Ph. D. Student | 12 | 12% |
Student > Doctoral Student | 6 | 6% |
Other | 17 | 18% |
Unknown | 13 | 13% |
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Neuroscience | 8 | 8% |
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Psychology | 5 | 5% |
Other | 18 | 19% |
Unknown | 20 | 21% |