Title |
Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach
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Published in |
Proteome Science, August 2011
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DOI | 10.1186/1477-5956-9-49 |
Pubmed ID | |
Authors |
Jairam Vanamala, Sridhar Radhakrishnan, Lavanya Reddivari, Vadiraja B Bhat, Andrey Ptitsyn |
Abstract |
We and others have previously reported that resveratrol (RSV) suppresses colon cancer cell proliferation and elevates apoptosis in vitro and/or in vivo, however molecular mechanisms are not fully elucidated. Particularly, little information is available on RSV's effects on metabolic pathways and the cell-extra cellular matrix (ECM) communication that are critical for cancer cell growth. To identify important targets of RSV, we analyzed whole protein fractions from HT-29 advanced human colon cancer cell line treated with solvent control, IGF-1 (10 nM) and RSV (150 μM) using LC/MS/MS-Mud PIT (Multidimensional Protein Identification Technology). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Chile | 1 | 2% |
Turkey | 1 | 2% |
Switzerland | 1 | 2% |
South Africa | 1 | 2% |
Unknown | 47 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 24% |
Student > Master | 9 | 18% |
Researcher | 7 | 14% |
Student > Bachelor | 6 | 12% |
Professor > Associate Professor | 5 | 10% |
Other | 6 | 12% |
Unknown | 6 | 12% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 19 | 37% |
Medicine and Dentistry | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
Chemistry | 3 | 6% |
Other | 4 | 8% |
Unknown | 10 | 20% |