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The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, March 2016
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Title
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast
Published in
Journal of Experimental & Clinical Cancer Research, March 2016
DOI 10.1186/s13046-016-0316-0
Pubmed ID
Authors

Haidan Jin, Meiying Ji, Liyan Chen, Qixiang Liu, Shuanlong Che, Ming Xu, Zhenhua Lin

Abstract

Mortalin/GRP75 is a ubiquitous mitochondrial chaperone which related to the cytosolic heat shock protein 70 (HSP70), and plays a role in carcinogenesis. This study aims to investigate the Mortalin expression in breast cancer and its correlation with the outcome of the patients with breast cancer. A total of 155 invasive ductal carcinoma of breast patients with strict follow-up, 52 ductal carcinoma in situ (DCIS) and 45 adjacent non-tumor breast tissues were selected for immunohistochemical (IHC) staining of Mortalin protein. The localization of Mortalin protein was detected in MDA-MB231 breast cancer cells using immunofluorescence (IF) staining. The correlations between overexpression of Mortalin and the clinical features of patients with breast cancer were evaluated using chi-square test and Fisher's exact tests. The survival rates were calculated by the Kaplan-Meier method, and the relationship between prognostic factors and patient survival was also analyzed by the Cox proportional hazard models. Mortalin protein showed a mainly cytoplasmic staining pattern in breast cancers by using IHC staining in paraffin embedded breast cancer tissues and IF staining in MDA-MB231 breast cancer cells. The strongly positive rate of Mortalin protein was 63.9 % (99/155) in invasive ductal carcinoma of breast and was significantly higher than in DCIS 34.6 % (18/52) and adjacent non-tumor tissues 15.6 % (7/45). Overexpression of Mortalin was closely correlated with histological grade, clinical stage, lymph node metastasis, lower disease free survival (DFS) and overall survival (OS) rates of patients with breast cancer. Moreover, multivariate analysis suggested that Mortalin emerged as a significant independent prognostic factor along with clinical stage and Her2 expression status in patients with breast cancer. Mortalin is upregulated in breast cancer, and may be a useful poor prognostic biomarker as well as a potential therapeutic target for patients with breast cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 24%
Student > Bachelor 3 14%
Other 2 10%
Researcher 2 10%
Student > Postgraduate 1 5%
Other 0 0%
Unknown 8 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 24%
Medicine and Dentistry 3 14%
Computer Science 1 5%
Agricultural and Biological Sciences 1 5%
Economics, Econometrics and Finance 1 5%
Other 1 5%
Unknown 9 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2016.
All research outputs
#6,385,109
of 7,380,153 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#265
of 386 outputs
Outputs of similar age
#234,753
of 277,989 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#24
of 30 outputs
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